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Review Article

December 25, 2025


Organoid drug screening in cancer: advances in high-throughput platforms and clinical applications
Jiho Lee, Hyun Ju Kang, Jin-Ku Lee
Organoid. 2025;5:e12.

Patient-derived tumor organoids represent the most physiologically relevant 3-dimensional (3D) cancer models, preserving tumor heterogeneity and native tissue architecture. However, their integration into high-throughput screening (HTS) platforms faces critical obstacles,...

Review Article

November 25, 2025


Three-dimensional bioprinting techniques for cancer: organoid models and applications
Janani Indrakumar, Akila Kesavan, M Joyce Nirmala
Organoid. 2025;5:e11.

Three-dimensional (3D) bioprinting has emerged as a promising technology for cancer research and treatment, offering unprecedented capabilities for fabricating complex tissue models and enabling personalized medicine. This review provides an...

Review Article

October 25, 2025


Brain organoids as versatile models for neurotropic virus research
Nhu Thi Quynh Mai, Byoung-San Moon
Organoid. 2025;5:e10.

The resurgence of neurotropic viruses capable of breaching the central nervous system (CNS) has intensified the demand for advanced in vitro models to clarify the mechanisms underlying cellular tropism, neuropathogenesis,...

Review Article

September 25, 2025


The evolving paradigm of organoids: advances in cell line-derived organoids with 3-dimensional printing and emerging technologies
Hyungjin Mun, Min Heui Yoo
Organoid. 2025;5:e9.

Organoid research has rapidly emerged as a prominent field within the life sciences, particularly in biomedical research. Stem cells represent the primary source of human organoids due to their exceptional...

Review Article

August 25, 2025


Bioprinted 3-dimensional lung organoids for respiratory disease modeling and therapeutic applications
Jimin Jang, Se-Ran Yang
Organoid. 2025;5:e8.

Advances in 3-dimensional (3D) lung models have created new opportunities in respiratory research, providing alternatives to conventional 2-dimensional cultures and animal models. Lung organoids, derived from pluripotent stem cells or...

Review Article

July 25, 2025


Organoid-derived extracellular vesicles: recent advances and therapeutic applications
Ahmed Abdal Dayem
Organoid. 2025;5:e7.

Extracellular vesicles (EVs) are crucial mediators of intercellular communication, transporting biologically active materials such as proteins, lipids, and nucleic acids. Although EVs derived from 2-dimensional (2D) monolayer cell cultures (2D-EVs)...

Review Article

June 25, 2025


Bone marrow organoid-based platforms overcoming barriers to predictive modeling of hematopoietic stem cell engraftment
Chaeyoun Lee, Yoonseo Choi, Hyejin Lee, et al.
Organoid. 2025;5:e6.

Hematopoietic stem cell transplantation (HSCT) has long served as an unparalleled therapeutic option for numerous hematologic malignancies and genetic disorders. However, the efficacy of HSCT is often limited by suboptimal...

Review Article

May 25, 2025


Organoid-based platforms for investigating microplastic-induced human organ toxicity
Yeongseon Cho, Hong Nam Kim
Organoid. 2025;5:e5.

Micro- and nano-plastics (MNPs) have emerged as widespread environmental contaminants, raising increasing concerns regarding their potential adverse effects on human health. Conventional in vitro and animal models have notable limitations...

Review Article

April 25, 2025


The role of RhoA/ROCK singaling pathway in organoid research
Jung Hwa Lim, Hyun Mi Kang, Cho-Rok Jung
Organoid. 2025;5:e4.

Rho-associated coiled-coil containing protein kinase (ROCK) signaling is a primary regulator of cell behavior in stem cell biology and organoid systems. This review examines the diverse roles of Rho/ROCK signaling...

Original Article

March 25, 2025


In vitro study: generation of a non-invasive patient-derived neurodegenerative model for spinocerebellar ataxia 6
Youngsun Lee, Mi-Ok Lee
Organoid. 2025;5:e3.

Background: Spinocerebellar ataxia (SCA) is a rare neurodegenerative disorder defined by genetic mutations that cause gait disturbances and impaired motor coordination. Among its subtypes, SCA6 arises from mutations in the...

Original Article

February 25, 2025


In vitro study on the comparison of hypoxia-inducible factor-1α expression after particulate matter exposure in 2-dimensional and 3-dimensional cell culture models
Ji-O Ryu, Eunyoung Lee, Sang-Yun Lee, et al.
Organoid. 2025;5:e2.

Background: Particulate matter (PM) can penetrate deep into the lungs, leading to diseases through the induction of hypoxia and inflammation. The hypoxia-inducible factor-1α (HIF-1α) protein is well-established as a key...

Review Article

January 25, 2025


A clinician’s perspective: what tumor-organoid researchers ought to know
Jeong Uk Lim
Organoid. 2025;5:e1.

Patient-derived tumor organoids (PDTOs) provide powerful platforms for modeling human tumors, offering insights into cancer biology and personalized therapy development. Incorporating clinical knowledge—such as cancer staging, molecular profiling, and treatment...
Current Issue
Volume 5; 2025
Organoid drug screening in cancer: advances in high-throughput platforms and clinical applications
Jiho Lee, Hyun Ju Kang, Jin-Ku Lee
Organoid. 2025;5:e12.

Review Article

Dec 25, 2025
Three-dimensional bioprinting techniques for cancer: organoid models and applications
Janani Indrakumar, Akila Kesavan, M Joyce Nirmala
Organoid. 2025;5:e11.

Review Article

Nov 25, 2025
Brain organoids as versatile models for neurotropic virus research
Nhu Thi Quynh Mai, Byoung-San Moon
Organoid. 2025;5:e10.

Review Article

Oct 25, 2025
The evolving paradigm of organoids: advances in cell line-derived organoids with 3-dimensional printing and emerging technologies
Hyungjin Mun, Min Heui Yoo
Organoid. 2025;5:e9.

Review Article

Sep 25, 2025
Bioprinted 3-dimensional lung organoids for respiratory disease modeling and therapeutic applications
Jimin Jang, Se-Ran Yang
Organoid. 2025;5:e8.

Review Article

Aug 25, 2025
Organoid-derived extracellular vesicles: recent advances and therapeutic applications
Ahmed Abdal Dayem
Organoid. 2025;5:e7.

Review Article

Jul 25, 2025
Bone marrow organoid-based platforms overcoming barriers to predictive modeling of hematopoietic stem cell engraftment
Chaeyoun Lee, Yoonseo Choi, Hyejin Lee, et al.
Organoid. 2025;5:e6.

Review Article

Jun 25, 2025
Organoid-based platforms for investigating microplastic-induced human organ toxicity
Yeongseon Cho, Hong Nam Kim
Organoid. 2025;5:e5.

Review Article

May 25, 2025
The role of RhoA/ROCK singaling pathway in organoid research
Jung Hwa Lim, Hyun Mi Kang, Cho-Rok Jung
Organoid. 2025;5:e4.

Review Article

Apr 25, 2025
In vitro study: generation of a non-invasive patient-derived neurodegenerative model for spinocerebellar ataxia 6
Youngsun Lee, Mi-Ok Lee
Organoid. 2025;5:e3.

Original Article

Mar 25, 2025
In vitro study on the comparison of hypoxia-inducible factor-1α expression after particulate matter exposure in 2-dimensional and 3-dimensional cell culture models
Ji-O Ryu, Eunyoung Lee, Sang-Yun Lee, et al.
Organoid. 2025;5:e2.

Original Article

Feb 25, 2025
A clinician’s perspective: what tumor-organoid researchers ought to know
Jeong Uk Lim
Organoid. 2025;5:e1.

Review Article

Jan 25, 2025

Organoid

Online ISSN: 2765-205X

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