Organoid

Review Article

December 25, 2024

Advancements in brain organoid models for neurodegenerative disease research

Soomin Park, Jong-Chan Park

Organoid. 2024;4:e12.

Neurodegenerative diseases (NDs) such as Parkinson’s disease (PD) and Alzheimer’s disease (AD) are progressive disorders characterized by complex, human-specific pathology that poses challenges to drug discovery efforts. Traditional models, including...

Review Article

November 25, 2024

Three-dimensional liver organoids as a novel platform for studying hepatitis B virus infection

Geon-Woo Kim

Organoid. 2024;4:e11.

Hepatitis B virus (HBV) infection is a major global health problem that contributes to chronic liver diseases, such as cirrhosis and hepatocellular carcinoma. Despite advances in antiviral therapy and the...

Original Article

October 25, 2024

Development of a microfluidic system with a bearing micropump for applying fluid shear force in an intervertebral disc degeneration model involving mechanical stimulation

Jae-Won Lee, Seoung Min Back, Tae-Won Kim, et al.

Organoid. 2024;4:e10.

Background: The intervertebral disc (IVD) functions as a shock absorber with viscoelastic tissues, including the gelatinous nucleus pulposus and the collagenous annulus fibrosus (AF). External mechanical loading influences IVD homeostasis...

Original Article

September 25, 2024

The regenerative capacity of hepatocyte organoids following long-term cryopreservation in Republic of Korea

Sun A Ock, Seo-Yeon Kim, Young-Im Kim, et al.

Organoid. 2024;4:e9.

Background: Hepatocyte organoids (HOs) are more functionally versatile than bile duct epithelial cell organoids, but have a shorter lifespan. This limitation has been improved by optimizing culture methods, but could...

Review Article

August 25, 2024

Transformative potential of three-dimensional bioprinting technology for advanced organoid research

Jungbin Yoon, Goeun Yoon, Jinah Jang

Organoid. 2024;4:e8.

Organoid research has emerged as a transformative field in biomedicine, focusing on the in vitro development of 3-dimensional (3D) structures that mimic human organs. Derived from various types of stem...

Review Article

July 25, 2024

Optical coherence tomography and its recent applications for three-dimensional imaging of organoids

Woo June Choi, Eun Seo Choi

Organoid. 2024;4:e7.

An organoid is a self-organizing, miniaturized model of an organ that recapitulates the architecture and physiology of the tissue of origin. With their high resemblance to the structure and function...

Review Article

June 25, 2024

Advances in cardiac organoid technology: current trends and standardized quality assessment for toxicity testing in preclinical models

Su-Jin Lee, Hyang-Ae Lee

Organoid. 2024;4:e6.

Cardiotoxicity is a prominent cause of drug withdrawal, impacting drug development during preclinical and clinical phases, as well as post-market approval. Traditional 2-dimensional cell culture models, despite being resource-rich, suffer...

Review Article

May 25, 2024

Developments in endoderm and pancreatic β-cell differentiation from human pluripotent stem cells

Dong Hyeon Lee, Hwajung Choo, Hyo Yi Choi, et al.

Organoid. 2024;4:e5.

Human pluripotent stem cells (hPSCs) can differentiate into any cell type in the body, including cells or tissues from ectodermal, mesodermal, or endodermal lineages. Type 1 diabetes is characterized by...

Review Article

April 25, 2024

Mimicking microbone tissue by 3-dimensional printing

Seung Yeon Lee, Jin Woo Lee

Organoid. 2024;4:e4.

Bones are mineralized connective tissues composed of osteoclasts, osteoblasts, and osteocytes. While bone is one of the few tissues that can regenerate in adulthood, its regeneration is limited in the...

Original Article

March 25, 2024

ERdj5-mediated regulation of proliferation and differentiation in colon organoids under inflammatory stress

Hyunjin Jeong, Jaewon Cho, Hyun-Jeong Ko

Organoid. 2024;4:e3.

Background: Endoplasmic reticulum (ER) stress is resolved by ERdj5, which functions as a disulfide reductase. In a previous study, we confirmed that ERdj5 was not indispensable for the formation of...

Original Article

February 25, 2024

Modelling Fabry disease with kidney organoids derived from human embryonic stem cells using CRISPR-Cas9 mediated gene editing

Su Jeong Lee, Kyung Jin Lee, Joo Hyun Jee, et al.

Organoid. 2024;4:e2.

Using gene editing to generate a nephron organoid model which recapitulates the hallmarks of human kidney disease is an attractive strategy, especially due to the potential for drug discovery in...

Review Article

January 25, 2024

Telencephalic organoids as model systems to study cortical development and diseases

Woo Sub Yang, Ferdi Ridvan Kiral, In-Hyun Park

Organoid. 2024;4:e1.

The telencephalon is the largest region of the brain and processes critical brain activity. Despite much progress, our understanding of the telencephalon’s function, development, and pathophysiological processes remains largely incomplete....

Current Issue: Volume 4; 2024

This archive contains links to the full-text of all issues of Organoid.

Current issue

Volume 4; 2024

All issues

Vol. 4
2024

v.4
2024

Vol. 3
2023

v.3
2023

Vol. 2
2022

v.2
2022

Vol. 1
2021

v.1
Jan 2021

Organoid

Online ISSN: 2765-205X

6,375	Inkjet-based bioprinting for tissue engineering
2,384	Advances in cardiac organoid technology: current trends and standardized quality assessment for toxicity testing in preclinical models
4,386	ERdj5-mediated regulation of proliferation and differentiation in colon organoids under inflammatory stress
4,962	Modelling Fabry disease with kidney organoids derived from human embryonic stem cells using CRISPR-Cas9 mediated gene editing
5,103	Telencephalic organoids as model systems to study cortical development and diseases

Cited By 4	Inkjet-based bioprinting for tissue engineering
Cited By 2	Engineered adipose tissue platforms: recent breakthroughs and future perspectives
Cited By 2	One-step achievement of tumor spheroid-induced angiogenesis in a high-throughput microfluidic platform: one-step tumor angiogenesis platform
Cited By 2	Tumor spheroid-based and microtumor-based vascularized models for replicating the vascularized tumor microenvironment
Cited By 2	Genome editing for engineering stem cell-derived pancreatic β cells: recent trends and future perspectives