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Organoid > Volume 1; 2021 > Article |
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Funding
This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2020R1I1A1A01051844) and the Bio & Medical Technology Development Program of the NRF funded by the Ministry of Science & ICT (2019M3A9H2032424, 2019M3E5D5064110). The sponsors had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Tissue/cell source | Differentiation | Disease modeling | Drug screening | Reference |
---|---|---|---|---|
• iPSCs from dermal fibroblasts | Proximal airway organoids | CF | - | [25] |
• iPSCs from cystic fibrosis donor | ||||
Human embryonic stem cell | Lung bud organoids | • RSV infection | - | [20] |
• Hermansky-Pudlak Syndrome-associated interstitial pneumonia | ||||
• Human fetal lung fibroblasts | Lung mesenchymal organoids | Idiopathic pulmonary fibrosis | - | [28] |
• iPSCs from adult lung tissue | ||||
Lung tissue from NSCLC | Not specified | Enterovirus infection | - | [27] |
Lung tissue from NSCLC | Proximal airway organoids | Influenza virus infection | - | [10] |
Non-tumor lung tissue | Proximal airway organoids | Influenza virus infection | - | [7] |
Bronchial airway tissue from NSCLC | Lung organoids | Cryptosporidium infection | - | [22] |
• Lung tissue from NSCLC | • Proximal airway organoids | • CF | Anti-cancer drugs (erlotinib, gefitinib, crizotinib, methotrexate, paclitaxel, nutilin-3a, alpelisib, cisplatin) | [8] |
• Bronchoalveolar lavage fluid from CF patients | • Lung tumor organoids | • RSV infection | ||
• Lung cancer | ||||
Human embryonic stem cells | Lung bud organoids | • HPIV3 | - | [26] |
• Recombinant measles virus | ||||
• iPSCs from amniotic fluid and neonatal foreskin | Lung organoids | Bochdalek congenital diaphragmatic hernia | - | [23] |
• Fetal/neonatal lung tissue | ||||
Lung cancer tissue from NSCLC | Lung cancer organoids | NSCLC | Chelerythrine chloride, cantharidin, harmine, betaine, berberine compounds | [24] |
Lung cancer tissue from NSCLC | Lung cancer organoids | NSCLC | Anti-cancer drugs (EGFR-TKIsa)and chemotherapy drugsb)) | [19] |
Lung tissue | Alveolar organoids | SARS-CoV-2 infection | - | [18] |
Lung tissue | • Proximal airway epithelial cells | SARS-CoV-2 infection | - | [17] |
• Alveolar organoids | ||||
Lung tissue | • Proximal airway epithelial cells | • SARS-CoV-2 infection | Zanamivir | [16] |
• Alveolar organoids | • Influenza virus H1N1 | |||
Human embryonic stem cells | Lung organoids | SARS-CoV-2 infection | Imatinib, mycophenolic acid, quinacrine dihydrochloride | [21] |
Human embryonic stem cells | Lung organoids | SARS-CoV-2 infection | Imatinib, mycophenolic acid, quinacrine dihydrochloride | [12] |
Lung tissue from deceased organ donors | • Proximal airway epithelial cells | SARS-CoV-2 infection | Hydroxychloroquine, remdesivir | [15] |
• Alveolar organoids |
Do Hyun Kim
https://orcid.org/0000-0002-9248-5572
Sung Won Kim
https://orcid.org/0000-0002-8981-2536
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