Organoid

Review Article

December 25, 2025

Organoid drug screening in cancer: advances in high-throughput platforms and clinical applications

Jiho Lee, Hyun Ju Kang, Jin-Ku Lee

Organoid. 2025;5:e12.

Patient-derived tumor organoids represent the most physiologically relevant 3-dimensional (3D) cancer models, preserving tumor heterogeneity and native tissue architecture. However, their integration into high-throughput screening (HTS) platforms faces critical obstacles,...

Review Article

November 25, 2025

Three-dimensional bioprinting techniques for cancer: organoid models and applications

Janani Indrakumar, Akila Kesavan, M Joyce Nirmala

Organoid. 2025;5:e11.

Three-dimensional (3D) bioprinting has emerged as a promising technology for cancer research and treatment, offering unprecedented capabilities for fabricating complex tissue models and enabling personalized medicine. This review provides an...

Review Article

October 25, 2025

Brain organoids as versatile models for neurotropic virus research

Nhu Thi Quynh Mai, Byoung-San Moon

Organoid. 2025;5:e10.

The resurgence of neurotropic viruses capable of breaching the central nervous system (CNS) has intensified the demand for advanced in vitro models to clarify the mechanisms underlying cellular tropism, neuropathogenesis,...

Review Article

September 25, 2025

The evolving paradigm of organoids: advances in cell line-derived organoids with 3-dimensional printing and emerging technologies

Hyungjin Mun, Min Heui Yoo

Organoid. 2025;5:e9.

Organoid research has rapidly emerged as a prominent field within the life sciences, particularly in biomedical research. Stem cells represent the primary source of human organoids due to their exceptional...

Review Article

August 25, 2025

Bioprinted 3-dimensional lung organoids for respiratory disease modeling and therapeutic applications

Jimin Jang, Se-Ran Yang

Organoid. 2025;5:e8.

Advances in 3-dimensional (3D) lung models have created new opportunities in respiratory research, providing alternatives to conventional 2-dimensional cultures and animal models. Lung organoids, derived from pluripotent stem cells or...

Review Article

July 25, 2025

Organoid-derived extracellular vesicles: recent advances and therapeutic applications

Ahmed Abdal Dayem

Organoid. 2025;5:e7.

Extracellular vesicles (EVs) are crucial mediators of intercellular communication, transporting biologically active materials such as proteins, lipids, and nucleic acids. Although EVs derived from 2-dimensional (2D) monolayer cell cultures (2D-EVs)...

Review Article

June 25, 2025

Bone marrow organoid-based platforms overcoming barriers to predictive modeling of hematopoietic stem cell engraftment

Chaeyoun Lee, Yoonseo Choi, Hyejin Lee, et al.

Organoid. 2025;5:e6.

Hematopoietic stem cell transplantation (HSCT) has long served as an unparalleled therapeutic option for numerous hematologic malignancies and genetic disorders. However, the efficacy of HSCT is often limited by suboptimal...

Review Article

May 25, 2025

Organoid-based platforms for investigating microplastic-induced human organ toxicity

Yeongseon Cho, Hong Nam Kim

Organoid. 2025;5:e5.

Micro- and nano-plastics (MNPs) have emerged as widespread environmental contaminants, raising increasing concerns regarding their potential adverse effects on human health. Conventional in vitro and animal models have notable limitations...

Review Article

April 25, 2025

The role of RhoA/ROCK singaling pathway in organoid research

Jung Hwa Lim, Hyun Mi Kang, Cho-Rok Jung

Organoid. 2025;5:e4.

Rho-associated coiled-coil containing protein kinase (ROCK) signaling is a primary regulator of cell behavior in stem cell biology and organoid systems. This review examines the diverse roles of Rho/ROCK signaling...

Original Article

March 25, 2025

In vitro study: generation of a non-invasive patient-derived neurodegenerative model for spinocerebellar ataxia 6

Youngsun Lee, Mi-Ok Lee

Organoid. 2025;5:e3.

Background: Spinocerebellar ataxia (SCA) is a rare neurodegenerative disorder defined by genetic mutations that cause gait disturbances and impaired motor coordination. Among its subtypes, SCA6 arises from mutations in the...

Original Article

February 25, 2025

In vitro study on the comparison of hypoxia-inducible factor-1α expression after particulate matter exposure in 2-dimensional and 3-dimensional cell culture models

Ji-O Ryu, Eunyoung Lee, Sang-Yun Lee, et al.

Organoid. 2025;5:e2.

Background: Particulate matter (PM) can penetrate deep into the lungs, leading to diseases through the induction of hypoxia and inflammation. The hypoxia-inducible factor-1α (HIF-1α) protein is well-established as a key...

Review Article

January 25, 2025

A clinician’s perspective: what tumor-organoid researchers ought to know

Jeong Uk Lim

Organoid. 2025;5:e1.

Patient-derived tumor organoids (PDTOs) provide powerful platforms for modeling human tumors, offering insights into cancer biology and personalized therapy development. Incorporating clinical knowledge—such as cancer staging, molecular profiling, and treatment...

Current Issue: Volume 5; 2025

Optical coherence tomography and its recent applications for three-dimensional imaging of organoids Woo June Choi, Eun Seo Choi Organoid. 2024;4:e7. Cited By 3 Review Article Jul 25, 2024 Full text PubReader ePub PDF	Transformative potential of three-dimensional bioprinting technology for advanced organoid research Jungbin Yoon, Goeun Yoon, Jinah Jang Organoid. 2024;4:e8. Cited By 3 Review Article Aug 25, 2024 Full text PubReader ePub PDF
Organoid-based platforms for investigating microplastic-induced human organ toxicity Yeongseon Cho, Hong Nam Kim Organoid. 2025;5:e5. Cited By 2 Review Article May 25, 2025 Full text PubReader ePub PDF	Mimicking microbone tissue by 3-dimensional printing Seung Yeon Lee, Jin Woo Lee Organoid. 2024;4:e4. Cited By 2 Review Article Apr 25, 2024 Full text PubReader ePub PDF
Developments in endoderm and pancreatic β-cell differentiation from human pluripotent stem cells Dong Hyeon Lee, Hwajung Choo, Hyo Yi Choi, et al. Organoid. 2024;4:e5. Cited By 2 Review Article May 25, 2024 Full text PubReader ePub PDF	Advancements in brain organoid models for neurodegenerative disease research Soomin Park, Jong-Chan Park Organoid. 2024;4:e12. Cited By 2 Review Article Dec 25, 2024 Full text PubReader ePub PDF
Telencephalic organoids as model systems to study cortical development and diseases Woo Sub Yang, Ferdi Ridvan Kiral, In-Hyun Park Organoid. 2024;4:e1. Cited By 1 Review Article Jan 25, 2024 Full text PubReader ePub PDF	The regenerative capacity of hepatocyte organoids following long-term cryopreservation in Republic of Korea Sun A Ock, Seo-Yeon Kim, Young-Im Kim, et al. Organoid. 2024;4:e9. Cited By 1 Original Article Sep 25, 2024 Full text PubReader ePub PDF

Organoid

Online ISSN: 2765-205X

10,405	Telencephalic organoids as model systems to study cortical development and diseases
3,282	Organoid-based platforms for investigating microplastic-induced human organ toxicity
3,430	In vitro study on the comparison of hypoxia-inducible factor-1α expression after particulate matter exposure in 2-dimensional and 3-dimensional cell culture models
2,575	Bone marrow organoid-based platforms overcoming barriers to predictive modeling of hematopoietic stem cell engraftment
6,679	Mimicking microbone tissue by 3-dimensional printing

Cited By 3	Optical coherence tomography and its recent applications for three-dimensional imaging of organoids
Cited By 3	Transformative potential of three-dimensional bioprinting technology for advanced organoid research
Cited By 2	Mimicking microbone tissue by 3-dimensional printing
Cited By 2	Developments in endoderm and pancreatic β-cell differentiation from human pluripotent stem cells
Cited By 2	Advancements in brain organoid models for neurodegenerative disease research