Organoid

Original Article

November 25, 2022

Alveolar organoids: development of an in vitro assay to facilitate pulmonary toxicity assessments

Jooyeon Lee, Hyosin Baek, Seok-Ho Hong, et al.

Organoid. 2022;2:e31.

Animal experiments have been performed to predict toxicity in humans in many fields, including toxicology, medicine, and pharmacology, and have contributed to increasing life expectancy. However, animal testing has been...

Original Article

October 25, 2022

Generation of proximal tubule spheroids for nephrotoxicity assessment

Dae Hun Kim, Jung Hwa Lim, Cho-Rok Jung, et al.

Organoid. 2022;2:e30.

To date, nephrotoxicity in new drug development has been evaluated through two-dimensional culture of representative cell lines, such as HK-2 and human proximal tubule epithelial cells (hPTECs). Approximately 20% of...

Review Article

November 25, 2022

Stress granule formation as a marker of cellular toxicity in lung organoids

Seung-Yeon Kim, Kee K. Kim, Eun-Mi Kim

Organoid. 2022;2:e28.

Cells regulate protein synthesis under stressful circumstances by forming cytoplasmic RNA granules, termed stress granules (SGs). SGs are membrane-less organelles that function as a protective mechanism in response to stress....

Review Article

December 25, 2022

Gastric stem cell research and gastric organoids

Haengdueng Jeong, Ki Taek Nam

Organoid. 2022;2:e27.

The stomach is a complex organ lined with ordered epithelium consisting of different adult stem cell (ASC) pools. In the previous decade, research into gastric epithelial stem cells has been...

Review Article

October 25, 2022

Recent advances in multicellular human liver models

Seon Ju Mun, Jaeseo Lee, Yongbo Shin, et al.

Organoid. 2022;2:e26.

The liver is the most important metabolic organ in the body. Model systems that recapitulate the complex organ structure and cell composition of the human liver are insufficient to study...

Original Article

August 25, 2022

A brain metastasis model for breast cancer using human embryonic stem cell-derived cerebral organoids

Mu Seog Choe, Min Young Lee

Organoid. 2022;2:e25.

Background: Breast cancer is a common cause of brain metastasis. Although breast cancer has relatively high survival rates, its survival rate after metastasis to the brain is lower. Conventional two-dimensional...

Review Article

September 25, 2022

Methods to identify epithelial stem cells

Youngtae Jeong

Organoid. 2022;2:e24.

Epithelial tissue is a tissue type that mainly covers the surfaces of the body and organs. Most epithelial tissues are composed of highly proliferative cells, necessitating robust stem cell activity....

Original Article

September 25, 2022

Generation of human-induced pluripotent stem cell-derived adherent 3-dimensional skin hair-follicle organoids

Mai Thi Quynh Nhu, Ulziituya Batjargal, Hyeon Song, et al.

Organoid. 2022;2:e23.

Regenerating hair follicles (HFs) is a critical medical need for patients who suffer from serious hair loss. To generate equivalent hair-bearing skin systems that could mimic the complexity of native...

Review Article

August 25, 2022

Clinical applications and optimization of patient-derived organoids in intestinal diseases

Tae Il Kim

Organoid. 2022;2:e22.

Since the first successful establishment of organoids from adult intestinal stem cells, organoid technology has rapidly developed. With advances in normal organoid technology, intestinal disorders, such as colorectal tumors and...

Review Article

October 25, 2022

Toward brain organoid-based precision medicine in neurodegenerative diseases

Jong-Chan Park, Inhee Mook-Jung

Organoid. 2022;2:e21.

In recent years, the concept of precision medicine—an approach to developing personalized drugs for disease prevention or treatment—has emerged as an up-and-coming field in medical research. However, there are numerous...

Original Article

September 25, 2022

Negative regulation of CDKN1A by the histone methyltransferase EHMT2 for cell growth in colorectal cancer

Kwangho Kim, Dae-Soo Kim, Mi-Young Son, et al.

Organoid. 2022;2:e20.

The epigenetic regulation of oncogenes and tumor suppressor genes by histone methyltransferases is an important process for colon cancer growth and metastasis. Although various epigenetic modifiers have been recognized as...

Original Article

July 25, 2022

A method for culturing patient-derived lung cancer organoids from surgically resected tissues and biopsy samples

Yu Ri Ko, Ji Min Kim, Younsoo Kang, et al.

Organoid. 2022;2:e19.

Cancer model systems that maintain the genetic and phenotypic characteristics of human cancers are crucial for the study of precision cancer medicine. In this respect, patient-derived cancer organoids have been...

Review Article

August 25, 2022

Technical advances in pluripotent stem cell-derived and tumorigenic organoids

Suwon Kang, Eun Kyung Bong, Hyo-Min Kim, et al.

Organoid. 2022;2:e18.

Cell culture systems have been widely used to address fundamental questions in biology without sacrificing animals. Three-dimensional (3D) organoids provide more information on in vivo conditions than traditional culture systems...

Review Article

July 25, 2022

Advanced human liver models for the assessment of drug-induced liver injury

Seon Ju Mun, Jaeseo Lee, Yongbo Shin, et al.

Organoid. 2022;2:e17.

Drug safety issues continue to occur even with drugs that are approved after the completion of clinical studies. Drug-induced liver injury (DILI) is a major obstacle to drug development, because...

Review Article

June 25, 2022

Understanding the cellular pathogenesis of COVID-19 symptoms using organoid technology

Young Hyun Che, Yong Jun Kim

Organoid. 2022;2:e16.

Patients with coronavirus disease 2019 (COVID-19), which has recently caused a pandemic, have reported symptoms of coronavirus infection that are not well understood by the medical community in general. After...

Review Article

July 25, 2022

Disease modeling in organoid cultures: a new tool for studying viruses

Jaewon Cho, Eun-Hye Hong, Hyun-Jeong Ko

Organoid. 2022;2:e15.

In vitro experiments have been widely used for more than a century to elucidate molecular mechanisms in cells and pathogen-host interactions, as well as for drug screening. Cell lines have...

Original Article

May 25, 2022

Three-dimensional cardiac organoid formation accelerates the functional maturation of human induced pluripotent stem cell-derived cardiomyocytes

Hanbyeol Lee, Jeong Suk Im, Da Bin Choi, et al.

Organoid. 2022;2:e14.

Human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes (CMs) offer a promising source for heart regeneration, disease modeling, and drug screening. Recent developments in organoid technology have made it possible to...

Editorial

June 25, 2022

Applications of human brain organoids

Alysson Renato Muotri

Organoid. 2022;2:e13.

Review Article

April 25, 2022

Progress, prospects, and limitations of organoid technology

Jin Hee Park, Do Gyeung Byeun, Jung Kyu Choi

Organoid. 2022;2:e9.

Organoids are mini-organs generated through in vitro 3-dimensional culture that mimic some of the structural and physiological functions of real organs. In recent research, various organoids have been derived from...

Review Article

March 25, 2022

Fundamental signaling pathways for glioblastoma drug resistance and developing robust organoid models for drug discovery

Athira Pratap, Eun-Jung Lim, Ihn-Sil Kwak, et al.

Organoid. 2022;2:e8.

This article presents a review of the current literature on the molecular mechanisms of treatment resistance in glioblastoma. As mounting research continues to explore novel methods of treating glioblastoma, from...

Review Article

February 25, 2022

Glioblastoma organoid technology: an emerging preclinical models for drug discovery

Don Carlo Ramos Batara, Shuchang Zhou, Moon-Chang Choi, et al.

Organoid. 2022;2:e7.

Glioblastoma multiforme (GBM) is the most prevalent type of primary brain tumor among adults, and it has a median overall survival of 12 to 15 months upon diagnosis. Despite significant...

Review Article

January 25, 2022

Recent advances in liver organoids and their use in in vitro modeling of non-alcoholic fatty liver disease

Kyun Yoo Chi, Jong-Hoon Kim

Organoid. 2022;2:e6.

The liver is involved in physiological activities critical for survival. Chronic liver disease (CLD) frequently progresses to life-threatening liver failure, as evidenced by CLD patients’ high morbidity and mortality rates....

Original Article

May 25, 2022

Standard operating protocol of hepatic organoid differentiation from human induced pluripotent stem cells

Min Jung Kim, Jaeseo Lee, Seon Ju Mun, et al.

Organoid. 2022;2:e5.

Mature liver organoids are promising cell sources for research to understand the pathology underlying a variety of conditions affecting the liver, including end-stage chronic liver disease. Although several methods exist...

Review Article

April 25, 2022

Recent advances and challenges in organoid-on-a-chip technology

Intan Rosalina Suhito, Tae-Hyung Kim

Organoid. 2022;2:e4.

Conventional 2-dimensional cell culture poorly mimics human-relevant models, which is considered a major challenge in biological research. Organoids are a recent breakthrough in 3-dimensional (3D) in vitro tissue engineering that...

Review Article

January 25, 2022

The application of intestinal organoids and their co-culture systems in the study of gastrointestinal diseases

Panida Sittipo, Yun Kyung Lee

Organoid. 2022;2:e3.

The 3-dimensional culture of intestinal organoids provides insights into the phenotype and physiology of the intestine. Intestinal organoids comprise intestinal stem cells and differentiated intestinal epithelial cells; they can be...

Review Article

March 25, 2022

Emerging organoid-based platforms to study salivary gland hypofunction

Yoojin Seo, Hyung-Sik Kim

Organoid. 2022;2:e2.

Xerostomia is a pathologic condition of hyposalivation due to salivary gland (SG) dysfunction. Although xerostomia significantly affects the quality of patients’ life, there is no satisfactory treatment for this disease....

Review Article

February 25, 2022

Biomimetic in vitro heart platforms for drug development

Sungwoo Cho, Sungho Ko

Organoid. 2022;2:e1.

New drug development is currently very expensive and time-consuming. In addition, some drugs that are approved after animal and clinical trials have their approval revoked because of adverse effects. About...

Human brain organoids in Alzheimer’s disease You Jung Kang, Hansang Cho Organoid. 2021;1:e5. Cited By 4 Review Article Mar 15, 2021 Full text PubReader ePub PDF	Engineered models for studying blood-brain-barrier-associated brain physiology and pathology Hong Nam Kim Organoid. 2021;1:e10. Cited By 2 Review Article Jun 15, 2021 Full text PubReader ePub PDF
Progress, prospects, and limitations of organoid technology Jin Hee Park, Do Gyeung Byeun, Jung Kyu Choi Organoid. 2022;2:e9. Cited By 1 Review Article Apr 25, 2022 Full text PubReader ePub PDF	Lung organoids: target cells for understanding respiratory diseases Jooyeon Lee, Se-Ran Yang Organoid. 2021;1:e4. Cited By 1 Review Article Feb 15, 2021 Full text PubReader ePub PDF
Disease modeling and drug screening using human airway organoids: a systematic review Do Hyun Kim, Sung Won Kim Organoid. 2021;1:e8. Cited By 1 Review Article May 15, 2021 Full text PubReader ePub PDF Supplementary Material

2,803	Trends in the global organoid technology and industry: from organogenesis in a dish to the commercialization of organoids
2,893	Biomimetic in vitro heart platforms for drug development
6,147	Human brain organoids in Alzheimer’s disease
2,749	Engineered models for studying blood-brain-barrier-associated brain physiology and pathology
2,357	Recent advances and challenges in organoid-on-a-chip technology

Cited By 4	Human brain organoids in Alzheimer’s disease
Cited By 2	Engineered models for studying blood-brain-barrier-associated brain physiology and pathology
Cited By 1	Lung organoids: target cells for understanding respiratory diseases
Cited By 1	Disease modeling and drug screening using human airway organoids: a systematic review
Cited By 1	Progress, prospects, and limitations of organoid technology