Organoid

Review Article

July 25, 2022

Advanced human liver models for the assessment of drug-induced liver injury

Seon Ju Mun, Jaeseo Lee, Yongbo Shin, et al.

Organoid. 2022;2:e17.

Drug safety issues continue to occur even with drugs that are approved after the completion of clinical studies. Drug-induced liver injury (DILI) is a major obstacle to drug development, because...

Review Article

June 25, 2022

Understanding the cellular pathogenesis of COVID-19 symptoms using organoid technology

Young Hyun Che, Yong Jun Kim

Organoid. 2022;2:e16.

Patients with coronavirus disease 2019 (COVID-19), which has recently caused a pandemic, have reported symptoms of coronavirus infection that are not well understood by the medical community in general. After...

Review Article

July 25, 2022

Disease modeling in organoid cultures: a new tool for studying viruses

Jaewon Cho, Eun-Hye Hong, Hyun-Jeong Ko

Organoid. 2022;2:e15.

In vitro experiments have been widely used for more than a century to elucidate molecular mechanisms in cells and pathogen-host interactions, as well as for drug screening. Cell lines have...

Original Article

May 25, 2022

Three-dimensional cardiac organoid formation accelerates the functional maturation of human induced pluripotent stem cell-derived cardiomyocytes

Hanbyeol Lee, Jeong Suk Im, Da Bin Choi, et al.

Organoid. 2022;2:e14.

Human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes (CMs) offer a promising source for heart regeneration, disease modeling, and drug screening. Recent developments in organoid technology have made it possible to...

Editorial

June 25, 2022

Applications of human brain organoids

Alysson Renato Muotri

Organoid. 2022;2:e13.

Review Article

April 25, 2022

Progress, prospects, and limitations of organoid technology

Jin Hee Park, Do Gyeung Byeun, Jung Kyu Choi

Organoid. 2022;2:e9.

Organoids are mini-organs generated through in vitro 3-dimensional culture that mimic some of the structural and physiological functions of real organs. In recent research, various organoids have been derived from...

Review Article

March 25, 2022

Fundamental signaling pathways for glioblastoma drug resistance and developing robust organoid models for drug discovery

Athira Pratap, Eun-Jung Lim, Ihn-Sil Kwak, et al.

Organoid. 2022;2:e8.

This article presents a review of the current literature on the molecular mechanisms of treatment resistance in glioblastoma. As mounting research continues to explore novel methods of treating glioblastoma, from...

Review Article

February 25, 2022

Glioblastoma organoid technology: an emerging preclinical models for drug discovery

Don Carlo Ramos Batara, Shuchang Zhou, Moon-Chang Choi, et al.

Organoid. 2022;2:e7.

Glioblastoma multiforme (GBM) is the most prevalent type of primary brain tumor among adults, and it has a median overall survival of 12 to 15 months upon diagnosis. Despite significant...

Review Article

January 25, 2022

Recent advances in liver organoids and their use in in vitro modeling of non-alcoholic fatty liver disease

Kyun Yoo Chi, Jong-Hoon Kim

Organoid. 2022;2:e6.

The liver is involved in physiological activities critical for survival. Chronic liver disease (CLD) frequently progresses to life-threatening liver failure, as evidenced by CLD patients’ high morbidity and mortality rates....

Original Article

May 25, 2022

Standard operating protocol of hepatic organoid differentiation from human induced pluripotent stem cells

Min Jung Kim, Jaeseo Lee, Seon Ju Mun, et al.

Organoid. 2022;2:e5.

Mature liver organoids are promising cell sources for research to understand the pathology underlying a variety of conditions affecting the liver, including end-stage chronic liver disease. Although several methods exist...

Review Article

April 25, 2022

Recent advances and challenges in organoid-on-a-chip technology

Intan Rosalina Suhito, Tae-Hyung Kim

Organoid. 2022;2:e4.

Conventional 2-dimensional cell culture poorly mimics human-relevant models, which is considered a major challenge in biological research. Organoids are a recent breakthrough in 3-dimensional (3D) in vitro tissue engineering that...

Review Article

January 25, 2022

The application of intestinal organoids and their co-culture systems in the study of gastrointestinal diseases

Panida Sittipo, Yun Kyung Lee

Organoid. 2022;2:e3.

The 3-dimensional culture of intestinal organoids provides insights into the phenotype and physiology of the intestine. Intestinal organoids comprise intestinal stem cells and differentiated intestinal epithelial cells; they can be...

Review Article

March 25, 2022

Emerging organoid-based platforms to study salivary gland hypofunction

Yoojin Seo, Hyung-Sik Kim

Organoid. 2022;2:e2.

Xerostomia is a pathologic condition of hyposalivation due to salivary gland (SG) dysfunction. Although xerostomia significantly affects the quality of patients’ life, there is no satisfactory treatment for this disease....

Review Article

February 25, 2022

Biomimetic in vitro heart platforms for drug development

Sungwoo Cho, Sungho Ko

Organoid. 2022;2:e1.

New drug development is currently very expensive and time-consuming. In addition, some drugs that are approved after animal and clinical trials have their approval revoked because of adverse effects. About...

Current Issue: Volume 2; 2022

Human brain organoids in Alzheimer’s disease

You Jung Kang, Hansang Cho

Organoid. 2021;1:e5.

Cited By 1

Review Article

Mar 15, 2021

Organoid

Online ISSN: 2765-205X

4,613	Human brain organoids in Alzheimer’s disease
4,847	Endoplasmic reticulum stress and organoids
2,050	Disease modeling and drug screening using human airway organoids: a systematic review
5,866	Lung organoids: target cells for understanding respiratory diseases
1,305	Biomimetic in vitro heart platforms for drug development